Rerunning cells out of order can lead to pain, that’s for sure. I must admit that it is rarely a problem for me. When I work in a notebook, I tend execute cells from top to bottom anyway in one fell swoop/button click (the effect is similar to running a Python script from the command line). Also, when I work interactively in an IDE (running things in the REPL), I also have to reload updated functions as well (assuming no auto reload has been set up), so in that sense there is still a pain there that is no different than using a notebook. Lots of work flows with different trade-offs I guess.
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