Yes Anvil is framework agnostic, kind of…
Pro Tip: Whenever you see Security then 9/10 times you are looking at Framework Limitations in all reference documentation.
My recommendation:
First build your solution in Anvil.Works, then export the Anvil App to your GitHub and get the .py and .yaml files.
Secondly, rebuild the app by editing/importing the Anvil code, line for line, into a Django App @ https://www.djangoproject.com/
And then Finally; Test and deploy your Django app for production with a port to https://www.lino-framework.org/ so that you’ll be able to handle all the data responsibly.
Hope that helps!